The services we offer
MorphCryst Consulting can offer support and guidance in the various elements of solid-state science and compound crystallisation
- Process review, data interpretation and recommendation
- Intellectual property (IP) review
- Process Analytical Technology (PAT)
- Material characterisation data interpretation
- Powder crystallography
- Thermal properties
- Composition
- FTIR spectroscopy
- Particle habit and size
- Behavior to variable humidity
- Single crystal structure solution
- Variable temperature and variable humidity XRPD
- Solid-State discovery investigations for candidate selection
- Salt and cocrystal formation - improve material characteristics.
- Polymorphism - establish propensity and identify appropriate crystalline form and amorphous solids.
- Version - composition variation via hydrate and solvate formation, inter-relationships.
- Preformulation - aid subsequent drug substance development.
- Crystallisation investigation and development
- Including use of in silico modelling in order to produce drug substance or material reliably with required attributes.
- Particle morphology, size control and particle design
- Improve isolation, aid downstream product development.
- Troubleshooting crystallisation scale up
- Oiling out, slow filtration, impurity control, compounds which are challenging to manipulate.
- Mechanical particle size reduction
- Aid subsequent product development.
